P2 receptor antagonist PPADS inhibits mesangial cell proliferation in experimental mesangial proliferative glomerulonephritis
نویسندگان
چکیده
منابع مشابه
Gene expression profile in experimental mesangial proliferative glomerulonephritis.
We analyzed gene expression in rat anti-Thy1 antibody-induced glomerulonephritis by using the cDNA microarray method. Ninety-seven genes that differed by more than 1.5-fold intensity in comparison with the controls were selected. Cluster analysis showed that the expression of genes associated with inflammation reached maximum levels at 24 h, while genes involved in the development of fibrosis i...
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Reactive oxygen species (ROS) are increasingly believed to be important intracellular signaling molecules in mitogenic pathways involved in the pathogenesis of glomerulonephritis (GN). We explored the effects of the antioxidants alpha-lipoic acid and N-acetyl-l-cysteine on ERK activation in cultured mesangial cells and the role of ERK activation in the severity of glomerular injury in a rat mod...
متن کاملStimulation of Soluble Guanylyl Cyclase (sGC) Inhibits Mesangial Cell Proliferation and Matrix Accumulation in Experimental Glomerulonephritis
Background: To date no specific treatment is established in mesangial proliferative glomerulonephritis in man. Specific stimulation of soluble guanylyl cyclase (sGC), an enzyme catalyzing the synthesis of cyclic GMP from GTP, can be achieved by the novel pyrazolopyridine derivative Bay 41-2272. In this study, we investigated the effects of sGC stimulation in experimental mesangial proliferative...
متن کاملStimulation of soluble guanylyl cyclase inhibits mesangial cell proliferation and matrix accumulation in experimental glomerulonephritis.
To date, no specific treatment is established in mesangial proliferative glomerulonephritis in humans. Specific stimulation of soluble guanylyl cyclase (sGC), an enzyme catalyzing the synthesis of cGMP from GTP, can be achieved by the novel pyrazolopyridine derivative BAY 41-2272. The effect of sGC stimulation via BAY 41-2272 on mesangial proliferation was assessed in vivo using a mesangial pro...
متن کاملThe role of the mesangial cell in proliferative glomerulonephritis.
In 40 patients with a histological diagnosis of proliferative glomerulonephritis the deposition of immunoglobulins, complement (C(3)), and fibrin/fibrinogen has been assessed by immunofluorescence and electron microscopy. The results of such examinations have been correlated with the outcome of the illness. In minor or resolving disease there is usually minor functional impairment, a good respo...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2002
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.2002.00621.x